Vaccination is a common routine for prevention and control of human and animal diseases by inducing antibody responses and cell-mediated immunity in the body. Through vaccinations, smallpox and some other diseases have been eradicated in the past few years. The use of a patho- gen itself or a subunit domain of a protein antigen as immunogens lays the basis for traditional vaccine development. But there are more and more newly emerged pathogens which have expe- rienced antigenic drift or shift under antibody selective pressures, rendering vaccine-induced im- munity ineffective. In addition, vaccine development has been hampered due to problems includ- ing difficulties in isolation and culture of certain pathogens and the antibody-dependent enhancement of viral infection (ADE). How to induce strong antibody responses, especially neu- tralizing antibody responses, and robust cell-mediated immune responses is tricky. Here we re- view the progress in vaccine development from traditional vaccine design to reverse vaccinology and structural vaccinology and present with some helpful perspectives on developing novel vac- cines.
The subject of this review article is the monograph of the academician Zuzanna Topolińska Polski ~ macedoński: konfrontacja (nie tylko) gramatyczna. 10: Spirala ewolucji (Wrocław: Wrocławskie Towarzystwo Naukowe, 2015), dedicated to the history and typology of Polish, Macedonian and other Slavic languages, refl ecting the many years of fruitful experience of Zuzanna Topolińska in research in this area, as well as in linguistic theory. The author of the review article emphasizes the novelty of this monograph, and the relevance of the issues considered in it, as well as the great importance of the book for Slavic and General linguistics.
The rules and guidelines for integrated pest management specified in Annex III, sections 2 and 3, state “General principles of integrated pest management”: Harmful organisms must be monitored by adequate methods and tools, where available. Such adequate tools should include observations in the field as well as scientifically sound warnings, forecasting and early diagnostic systems, where feasible, as well as advice from professionally qualified advisors. As part of Multiannual Programs, the Institute of Plant Protection – NRI in Poznań has been carrying out work and research for many years to develop or modify guidelines for monitoring short- and long-term forecasting of pest occurrence on crops. These guidelines are extremely helpful for farmers and advisers in determining the optimum date of chemical control of pests on plants. Regularly revised and improved the guidelines deal with pests which currently pose a threat to crops. They are developed according to the latest scientific findings and are successfully promoted among professional users and agricultural advisors. These guidelines are standardized to include descriptions of species, life cycles, symptoms of damage/infestation of crops, methods of observation targeted at warning of the need for plant protection treatments, and threshold values of harmfulness. All guidelines include extensive photographic material. Guidelines for the monitoring of pests on orchard plants, vegetables and others are prepared at the Institute of Soil Science and Plant Cultivation − NRI in Puławy and the Institute of Pomology in Skierniewice. Guidelines for about 80 pests of crops are available for public use in the on-line Pest Warning System (Platforma Sygnalizacji Agrofagów, www.agrofagi.com.pl).
This review paper presents research results on geodetic positioning and applications carried out in Poland, and related to the activities of the International Association of Geodesy (IAG) Commission 4 “Positioning and Applications” and its working groups. It also constitutes the chapter 4 of the national report of Poland for the International Union of Geodesy and Geodynamics (IUGG) covering the period of 2015-2018. The paper presents selected research, reviewed and summarized here, that were carried out at leading Polish research institutions, and is concerned with the precise multi-GNSS (Global Navigation Satellite Systems) satellite positioning and also GNSS-based ionosphere and troposphere modelling and studies. The research, primarily carried out within working groups of the IAG Commission 4, resulted in important advancements that were published in leading scientific journals. During the review period, Polish research groups carried out studies on multi-GNSS functional positioning models for both relative and absolute solutions, stochastic positioning models, new carrier phase integer ambiguity resolution methods, inter system bias calibration, high-rate GNSS applications, monitoring terrestrial reference frames with GNSS, assessment of the real-time precise satellite orbits and clocks, advances in troposphere and ionosphere GNSS remote sensing methods and models, and also their applications to weather, space weather and climate studies.
This paper summarizes the activity of the chosen Polish geodetic research teams in 2015–2018 in the fields of Earth: rotation, dynamics as well as magnetic field. It has been prepared for the needs of the presentation on the 27th International Union of Geodesy and Geodynamics General Assembly, Montreal, Canada. The part concerning Earth rotation is mostly focused on the use of modelling of diurnal and subdiurnal components of Earth rotation by including low frequency components of polar motion and UT1 in the analysis, study of free oscillations in Earth rotation derived from both space-geodetic observations of polar motion and the time variation of the second degree gravitational field coefficients derived from Satellite Laser Ranging (SLR) and Gravity Recovery and Climate Experiment (GRACE) observations, new methods of monitoring of Earth rotation, as well as studies on applications of the Ring Laser Gyroscope (RLG) for direct and continuous measurements of changes in Earth rotation and investigations of the hydrological excitation of polar motion. Much attention was devoted to the GRACE-derived gravity for explaining the influence of surface mass redistributions on polar motion. Monitoring of the geodynamical phenomena is divided into study on local and regional dynamics using permanent observations, investigation on tidal phenomena, as well as research on hydrological processes and sea level variation parts. Finally, the recent research conducted by Polish scientists on the Earth’s magnetic field is described.
Noise Control is the most important international acoustics conference regularly organized in Poland. The XV International Conference Noise Control 2010 is taking place between June 6 and 9, 2010, in Ksi?? in Wa?brzych. It is organized by the Central Institute for Labour Protection - National Research Institute, the Committee on Acoustics of the Polish Academy of Sciences, the Polish Acoustical Society, with the cooperation of the Department of Mechanics and Vibroacoustics of the AGH University of Science and Technology, the Department of Acoustics of the Building Research Institute and the Chair of Acoustics of the Wroc?aw University of Technology.
Research activities of Polish research groups in a period of 2015–2019 on reference frames and reference networks are reviewed and summarised in this paper. The summary contains the results concerning the implementation of latest resolutions on reference systems of the International Union of Geodesy and Geophysics and the International Union of Astronomy with special emphasis on the changes in the Astronomical Almanac of the Institute of Geodesy and Cartography, Warsaw. It further presents the status of the implementation of the European Terrestrial Reference System 1989 (ETRS89) in Poland, monitoring the terrestrial reference frame, operational work of GNSS permanent IGS/EPN stations in Poland, operational work of the laser ranging station in Poland of the International Laser Ranging Service (ILRS), active GNSS station network for the realization of ETRS89 in Poland, validation of recent ETRS89 realization, expressed in ETRF2000 in Poland, and maintenance of the vertical control in Poland (PL-KRON86-NH). Extensive research activities are observed in the field of maintenance and modernization of gravity control not only in Poland, but also in Sweden and in Denmark, as well as establishment of gravity control in Ireland based on absolute gravity survey. The magnetic control in Poland was also regularly maintained. The bibliography of the related works is given in references.
Activities of the Polish research gSDroups concerning gravity field modelling and gravimetry in a period of 2015–2018 are reviewed and summarised in this paper. The summary contains the results of research on the evaluation of GOCE-based global geopotential models (GGMs) in Poland and geoid modelling. Extensive research activities are observed in the field of absolute gravity surveys, in particular for the maintenance of national gravity control in Poland, Sweden, Denmark, the Republic of Ireland and in Northern Ireland as well as for geodynamics with special emphasis on metrological aspects in absolute gravimetry. Long term gravity variations were monitored in two gravimetric laboratories: the Borowa Gora Geodetic-Geophysical Observatory, and Jozefoslaw Astrogeodetic Observatory with the use of quasi-regular absolute gravity measurements as well as tidal gravimeter records. Gravity series obtained were analysed considering both local and global hydrology effects. Temporal variations of the gravity field were investigated using data from GRACE satellite mission as well as SLR data. Estimated variations of physical heights indicate the need for kinematic realization of reference surface for heights. Also seasonal variability of the atmospheric and water budgets in Poland was a subject of investigation in terms of total water storage using the GLDAS data. The use of repeatable absolute gravity data for calibration/validation of temporal mass variations derived from satellite gravity missions was discussed. Contribution of gravimetric records to seismic studies was investigated. The bibliography of the related works is given in references.