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Abstract

This paper aims at elaborating the concept of linguistic self with regard to its twofold existence modes, namely as a physical person and as a mental subject, being shaped by external and internal dialogs in interpersonal and intersubjective communication. These dialogical encounters, constantly changing the reality of everyday life, are based, on the one hand, on the observable multitextuality of narratives, and on the other, on the multi-voicedness of opinions. As such, it lays emphasis on the need for a holistic approach to human beings as a psychosomatic unity, taking part in cognition with their minds and bodies, and developing itself both in-and-with the physical and logical domains of their surrounding ecosystems. In view of the private and public character of the self, the author postulates to consider in future studies the achievements of personal and social constructivism.
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Abstract

Constantly increasing prevalence of allergic diseases determines the attempts to elaborate the therapeutic strategies activating immune tolerance to particular allergen. Our current research focuses on the antigen-specifi c action of CD8+ suppressor T (Ts) lymphocytes induced in mice by intravenous administration of a high dose of haptenated syngeneic erythrocytes. While the regulatory activity of Ts cells mediated by exosome-delivered miRNA-150 is well defi ned, the mechanism of their induction remained unclear. Th erefore, the current studies investigated the immune eff ects induced in mice by intravenous administration of contact allergens coupled to syngeneic erythrocytes. In mouse models of hapten-induced contact hypersensitivity (CHS) and delayed-type hypersensitivity to ovalbumin, we have shown that intravenous administration of hapten-coupled erythrocytes failed to induce CHS effector cells. Moreover, hapten-induced CHS reaction occurred to be suppressed in mice intravenously administered with syngeneic erythrocytes coupled with protein allergen. Finally, we have demonstrated that intravenously administered allergen induces immune tolerance only when bound to syngeneic erythrocytes, proving that intravenously delivered allergens are deprived of their immunizing properties when coupled with membrane of self cells. Altogether, our current studies suggest that alteration of self cell membrane by allergen binding is enough to induce Ts cell-mediated immune tolerance to nonpathogenic agents, which express a great translational potential in such conditions as allergies and hypersensitivity-related autoimmune disorders.
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