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Abstract

The subject matter of this article constitutes the semiotic mapping of human of knowledge which results from cognition. Departing from the presentation of human subjects as world-model-builders, it places epistemology among the sciences of science and the sciences of man. As such the understanding of epistemology is referred either to a static state of knowledge or to a dynamic acquisition of knowledge by cognizing subjects. The point of arrival, in the conclusive part of a this article, constitutes the substantiation of the two understandings of epistemology, specified, firstly, as a set of investigative perspectives, which the subject of science has at his/her disposal as a knower on the metascientific level, or, secondly, as a psychophysiological endowment of a cognizing subject who possesses the ability of learning and/or knowing a certain kind of information about cognized reality.
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Abstract

This paper aims at elaborating the concept of linguistic self with regard to its twofold existence modes, namely as a physical person and as a mental subject, being shaped by external and internal dialogs in interpersonal and intersubjective communication. These dialogical encounters, constantly changing the reality of everyday life, are based, on the one hand, on the observable multitextuality of narratives, and on the other, on the multi-voicedness of opinions. As such, it lays emphasis on the need for a holistic approach to human beings as a psychosomatic unity, taking part in cognition with their minds and bodies, and developing itself both in-and-with the physical and logical domains of their surrounding ecosystems. In view of the private and public character of the self, the author postulates to consider in future studies the achievements of personal and social constructivism.
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Abstract

The results from a hydrological monitoring program of Breelva basin (Spitsbergen, Svalbard) have been analysed to improve the understanding of the Werenskiöld Glacier system’s functioning in the High Arctic. Hydrographs of a 44 km 2 river basin (27 km 2 of which was covered by a glacier) were analysed for the period 2007–2012. Seasonal discharge fluctuations were linked to glacier ablation and meteorological parameters, including atmospheric circulation types. A dichotomy was found in the discharge peaks generation during the hydrologically active season, with the main role played by snow and ice melt events during its first part and the rainfall regime dominating its second part. Foehn type strong winds played a significant role in the generation of ablation type floods ( e.g. in August 2011). A simple classification of the runoff regime was applied to the examined six−year period, resulting in the identification of its three types: the ablation type (dominant in 2007 and 2009), the rainfall type (in the years 2011–2012), and the mixed type (during 2008 and 2010). According to publications the river flow season in Spitsbergen begins in June and end with freeze−up in September or at the beginning of October. Recently, this season for Breelva tend to be extended with the mid−May onset and end in the second part of October. A multiannual trend was noted that reflects a growing importance of rainfalls, especially in September. Rainfall waters play a more distinct role in outflow from the Breelva catchment recently.
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Abstract

In this paper, the influence of Mo addition on the structure and mechanical properties of the NiCoMnIn alloys have been studied. Series of polycrystalline NiCoMnIn alloys containing from 0 to 5 mas.% of Mo were produced by the arc melting technique. For the alloys containing Mo, two-phase microstructure was observed. Mo-rich precipitates were distributed randomly in the matrix. The relative volume fraction of the precipitates depends on the Mo content. The numbers of the Mo rich precipitates increases with the Mo contents. The structures of the phases were determined by the TEM. The mechanical properties of the alloys are strongly affected by Mo addition contents. Brittleness of the alloys increases with the Mo contents.
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Abstract

Constantly increasing prevalence of allergic diseases determines the attempts to elaborate the therapeutic strategies activating immune tolerance to particular allergen. Our current research focuses on the antigen-specifi c action of CD8+ suppressor T (Ts) lymphocytes induced in mice by intravenous administration of a high dose of haptenated syngeneic erythrocytes. While the regulatory activity of Ts cells mediated by exosome-delivered miRNA-150 is well defi ned, the mechanism of their induction remained unclear. Th erefore, the current studies investigated the immune eff ects induced in mice by intravenous administration of contact allergens coupled to syngeneic erythrocytes. In mouse models of hapten-induced contact hypersensitivity (CHS) and delayed-type hypersensitivity to ovalbumin, we have shown that intravenous administration of hapten-coupled erythrocytes failed to induce CHS effector cells. Moreover, hapten-induced CHS reaction occurred to be suppressed in mice intravenously administered with syngeneic erythrocytes coupled with protein allergen. Finally, we have demonstrated that intravenously administered allergen induces immune tolerance only when bound to syngeneic erythrocytes, proving that intravenously delivered allergens are deprived of their immunizing properties when coupled with membrane of self cells. Altogether, our current studies suggest that alteration of self cell membrane by allergen binding is enough to induce Ts cell-mediated immune tolerance to nonpathogenic agents, which express a great translational potential in such conditions as allergies and hypersensitivity-related autoimmune disorders.
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