Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.
The drainage consolidation method has been efficiently used to deal with soft ground improvement. Nowadays, it has been suggested to use a new sand soil which is a composite of sand and recycled glass waste. The permeability performance of glass-sand soil was explored to judge the feasibility of glass-sand soil backfilled in the drainage consolidation of sand-drained ground. For comparison purposes, different mix proportions of recycled glass waste, fineness modulus, and glass particle size were analyzed to certify the impact on the permeability coefficient and the degree of consolidation. The numerical results show that adding a proper amount of recycled glass waste could promote the permeability performance of glass-sand soil, and the glasssand soil drain could be consolidated more quickly than a sand drain. Experiments showed that glass-sand soil with the a 20% mix of recycled glass waste reveals the optimum performance of permeability.